Green Coffee - Antabuse (Disulfiram) Interaction
Herbal: Green Coffee
Also Known As: Coffea arabica, Coffea canephora, Coffea bukobensis, Arabica Green Coffee Beans, Raw Coffee
Drug: Disulfiram
Brand names:
Antabuse
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Disulfiram is classified as belonging to the following category: Disulfiram (Antabuse)
Theoretically, disulfiram might increase the levels and adverse effects of caffeine.
Green coffee can contain caffeine. In human research, disulfiram decreases the clearance and increases the half-life of caffeine.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Beach CA, Mays DC, Guiler RC, et al. Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics. Clin Pharmacol Ther 1986;39:265-70.
Green Coffee Overview
Green coffee refers to coffee beans that have not been roasted (unlike regular coffee, which is roasted). They are typically a pale green color and have a mild, slightly bitter flavor.
One of the main differences between green coffee and regular coffee is the amount of chlorogenic acid they contain. Chlorogenic acid is a plant compound that is found in high levels in green coffee beans, but it is largely destroyed during the roasting process. As a result, green coffee has a higher concentration of chlorogenic acid than regular coffee.
Green coffee is often consumed as a supplement in the form of capsules, tablets, or powders, and is purported to have a number of potential health benefits. Some research suggests that green coffee may help with weight loss, lower blood pressure, and improve blood sugar control, but more data is needed for more definitive conclusions.
Disulfiram Overview
-
Disulfiram is used to treat chronic alcoholism. It causes unpleasant effects when even small amounts of alcohol are consumed. These effects include flushing of the face, headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety. These effects begin about 10 minutes after alcohol enters the body and last for 1 hour or more. Disulfiram is not a cure for alcoholism, but discourages drinking.
-
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Green Coffee - More Interactions
Green Coffee interacts with 665 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
Return to the main supplement interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
Ask A Pharmacist About Your Herbal Questions!
Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
Ask A Pharmacist