Medication interaction hub

What Supplements Interact with Disulfiram?

Disulfiram brand name: Antabuse. Every interaction below applies to the brands too.

45 Interactions 4 Major 30 Moderate 11 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Disulfiram? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Disulfiram against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

45 supplements and herbal ingredients have interactions with Disulfiram on file in the HelloPharmacist interaction database — 4 rated major, 30 moderate, and 11 minor. The most serious involve Bach Flower Remedies, Beer, Wine and Activated Charcoal.

Our assessment: with 4 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Disulfiram.

Major 4 Moderate 30 Minor 11 No known interaction 1,407

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Disulfiram: Top Interactions at a Glance

The most significant Disulfiram supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 45 interacting ingredients — plus 1,407 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Disulfiram + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Bach Flower Remedies + Disulfirami

Bach flower remedies can cause a disulfiram-like reaction when taken with disulfiram.

Read the full interaction Major Likelihood Likely Beer + Disulfirami

Concomitant use may cause a disulfiram reaction.

Read the full interaction Major Likelihood Likely Wine + Disulfirami

Concomitant use may cause a disulfiram reaction.

Read the full interaction Major Likelihood Probable Activated Charcoal + Disulfirami

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Disulfiram

All 1,452 ingredients in our database, ranked by severity — 45 with a Disulfiram interaction on file and 1,407 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Disulfiram?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cannabis with Disulfiram?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, drugs that are CYP2C9 inhibitors might increase the adverse effects of cannabis.

Full Cannabis + Disulfiram answer

Can you take Carob with Disulfiram?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Disulfiram answer

Can you take Kefir with Disulfiram?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking kefir with disulfiram might cause a disulfiram reaction.

Full Kefir + Disulfiram answer

Can you take Black Psyllium with Disulfiram?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Disulfiram answer

Can you take Blond Psyllium with Disulfiram?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Disulfiram answer

Can you take Karaya Gum with Disulfiram?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Disulfiram answer

Can you take Kombucha with Disulfiram?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, kombucha might cause a disulfiram reaction when taken with disulfiram.

Full Kombucha + Disulfiram answer

Can you take Marshmallow with Disulfiram?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Disulfiram answer

Can you take Xanthan Gum with Disulfiram?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Disulfiram answer

Can you take Bach Flower Remedies with Disulfiram?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Bach flower remedies can cause a disulfiram-like reaction when taken with disulfiram.

Full Bach Flower Remedies + Disulfiram answer

Can you take Beer with Disulfiram?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may cause a disulfiram reaction.

Full Beer + Disulfiram answer

Can you take Wine with Disulfiram?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may cause a disulfiram reaction.

Full Wine + Disulfiram answer

Can you take Activated Charcoal with Disulfiram?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Disulfiram answer

Can you take Black Tea with Disulfiram?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, disulfiram might increase the risk of adverse effects from caffeine.

Full Black Tea + Disulfiram answer

Can you take Caffeine with Disulfiram?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.

Full Caffeine + Disulfiram answer

Can you take Cocoa with Disulfiram?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, disulfiram might increase the risk of adverse effects from caffeine.

Full Cocoa + Disulfiram answer

Can you take Coffee with Disulfiram?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, disulfiram might increase the risk of adverse effects from caffeine.

Full Coffee + Disulfiram answer

Can you take Coffee Charcoal with Disulfiram?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Disulfiram answer

Can you take Cola Nut with Disulfiram?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, disulfiram might increase the levels and adverse effects of the caffeine in cola nut.

Full Cola Nut + Disulfiram answer

Can you take European Mandrake with Disulfiram?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Disulfiram answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Disulfiram is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Disulfiram, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Disulfiram sits in 4 interaction categories. Open any one to see what the group means:

Disulfiram (Antabuse) 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Disulfiram through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Disulfiram through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Disulfiram through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Disulfiram through this category.

About Disulfiram

Disulfiram is a medication used to discourage drinking in people with chronic alcoholism.

Generic name: Disulfiram  ·  Brand name: Antabuse.

See the full Disulfiram drug information

Related: does Disulfiram deplete any nutrients?

Disulfiram has 1 reported nutrient association in the research literature — see the Disulfiram nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Disulfiram

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Disulfiram.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Disulfiram-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Disulfiram.

Marine Collagen by Number One Nutrition contains Black Tea LHC+ by Number One Nutrition contains Black Tea Energy Complex by Nutricost contains Black Tea Senolytic Complex by SuperSmart contains Black Tea
Pharmacist Counseling Corner

Disulfiram & Supplements: Common Questions

What supplements interact with Disulfiram?
In our interaction database, 45 supplement and herbal ingredients have an interaction with Disulfiram on file — 4 rated major, 30 moderate, and 11 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Bach Flower Remedies, Beer, Wine.
Which Disulfiram supplement interactions are the most serious?
The 4 major-rated combinations — led by Bach Flower Remedies, Beer, Wine and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Disulfiram?
That depends entirely on which supplement. The honest answer for Disulfiram is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Antabuse have the same supplement interactions as Disulfiram?
Yes — Antabuse all contain Disulfiram, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Disulfiram deplete any vitamins or nutrients?
It might — Disulfiram has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Disulfiram nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Disulfiram and my other medications?
This page covers Disulfiram against supplements and herbal ingredients. Checking Disulfiram against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Disulfiram drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.