Drug Interaction Report

Dofetilide and Dolutegravir: Interaction Details

A pharmacist-reviewed analysis of the Dofetilide and Dolutegravir interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Dofetilide

Tikosyn Tikosyn®
+

Dolutegravir

Juluca® (as a combination product containing dolutegravir, rilpivirine) Tivicay Tivicay® Tivicay® PD
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Contraindicated
These should generally not be used together.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 454 documented Dofetilide interactions, 33 are rated contraindicated — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
probable
Severity
Contraindicated

What happens

Increased dofetilide exposure and risk of serious or life-threatening events

Interaction Deep Dive

Dolutegravir inhibited renal organic cation transporter 2 (OCT2) and multidrug and toxin extrusion transporter 1 (MATE1) in vitro (half maximal inhibitory concentration (IC(50)) = 1.93 and 6.34 micromolar, respectively) and inhibited OCT-2-mediated (and potentially inhibited MATE1) renal tubular secretion of creatinine in vivo. Concomitant use of dofetilide and dolutegravir may result in increased plasma concentrations of dofetilide, which is eliminated by OCT2 or MATE1, potentially increasing the risk for serious and/or life-threatening adverse events. Thus, the concomitant use of dofetilide and dolutegravir is contraindicated213.

Why it happens (mechanism)

Inhibition of renal organic cation transporter 2 (OCT2) and potentially multidrug and toxin extrusion transporter 1 (MATE1) by dolutegravir

Common questions

Can I take Dofetilide and Dolutegravir together?

Increased dofetilide exposure and risk of serious or life-threatening events Always confirm with your pharmacist or prescriber before making any change.

How serious is the Dofetilide and Dolutegravir interaction?

It is rated contraindicated. These should generally not be used together.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Dofetilide or Dolutegravir need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (3)

  1. Product Information: TRIUMEQ PD oral tablets for suspension, abacavir, dolutegravir, lamivudine oral tablets. ViiV Healthcare (per FDA), Research Triangle Park, NC, 2022. DailyMed
  2. Product Information: TRIUMEQ oral tablets, abacavir, dolutegravir, lamivudine oral tablets. ViiV Healthcare (per FDA), Research Triangle Park, NC, 2022. DailyMed
  3. Product Information: TIVICAY(R) oral tablets, dolutegravir oral tablets. ViiV Healthcare (per FDA), Research Triangle Park, NC, 2014. DailyMed
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Dofetilide

Keep reading about Dofetilide

All Dofetilide interactions (454) Dofetilide drug information
Also serious with: Bictegravir Cimetidine Saquinavir Cisapride
Dolutegravir

Keep reading about Dolutegravir

All Dolutegravir interactions (51) Dolutegravir drug information
Also serious with: Ensitrelvir Abametapir Cabotegravir Dalfampridine
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Dofetilide + Activated Charcoal American Hellebore Arsenic Cesium Ephedra Grapefruit Sida Cordifolia St. John's Wort + 138 more
Dolutegravir + Activated Charcoal Calcium St. John's Wort Bitter Melon Black Pepper Breadfruit Brussels Sprout Bulbine Natalensis + 57 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.