Donepezil

105 interactions 6 explained in plain English

Also sold as: Adlarity Aricept

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Octreotide Injection Gatifloxacin Ophthalmic Estradiol Penicillin V Potassium Relugolix Ofloxacin Otic

104 Major 1 Moderate

All (105) Major (104) Moderate (1)

Major

Donepezil Encorafenib Braftovi Increased risk of QT interval prolongation Details Donepezil Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Donepezil Epinastine Ophthalmic Elestat® Reduced seizure threshold Details Donepezil Eribulin Injection Halaven Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Estradiol Delestrogen Reduced seizure threshold Details Donepezil Estradiol Topical Divigel Reduced seizure threshold Details Donepezil Estradiol Transdermal Patch Alora® Reduced seizure threshold Details Donepezil Estramustine Emcyt Reduced seizure threshold Details Donepezil Famotidine Calmicid Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Famotidine Injection Calmicid Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Felbamate Felbatol Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Fentanyl Transdermal Patch Duragesic® Reduced seizure threshold Details Donepezil Flecainide Tambocor® Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Foscarnet Injection Foscavir Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Fostemsavir Rukobia Increased risk of torsade de pointes Details Donepezil Galantamine Razadyne Reduced seizure threshold; increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Gatifloxacin Ophthalmic Zymar® Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Gemifloxacin Factive Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Glasdegib Daurismo Increased risk of QT interval prolongation Details Donepezil Goserelin Implant Zoladex Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Granisetron Transdermal Patch Sancuso Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Granisetron Injection Granisol Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Histrelin Implant Supprelin Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Hydromorphone Injection Dilaudid Reduced seizure threshold Details Donepezil Hydromorphone Rectal available generically Reduced seizure threshold Details Donepezil Hydroxychloroquine Plaquenil Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Donepezil Ivabradine Corlanor Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Donepezil Ketotifen Alaway Reduced seizure threshold Details Donepezil Ketotifen Ophthalmic Alaway Reduced seizure threshold Details Donepezil Lefamulin Xenleta Increased risk of QT interval prolongation Details Donepezil Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Donepezil Levofloxacin Levaquin Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Levofloxacin Injection Levaquin Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Lindane Gamene® Reduced seizure threshold Details Donepezil Lithium Carbonate Lithobid Reduced seizure threshold Details Donepezil Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Donepezil Mefenamic Acid Ponstel® Reduced seizure threshold Details Donepezil Mefloquine Lariam® Increased risk of QT-interval prolongation and torsade de pointes Details

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