Donepezil and Gatifloxacin Ophthalmic: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Donepezil
Gatifloxacin Ophthalmic
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of QT-interval prolongation and torsade de pointes
Interaction Deep Dive
Donepezil has been associated with QT-interval prolongation12. Use caution when administering donepezil concomitantly with other drugs that cause QT-interval prolongation.
Why it happens (mechanism)
Additive QT-interval prolongation
Common questions
Can I take Donepezil and Gatifloxacin Ophthalmic together?
Increased risk of QT-interval prolongation and torsade de pointes Always confirm with your pharmacist or prescriber before making any change.
How serious is the Donepezil and Gatifloxacin Ophthalmic interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Donepezil or Gatifloxacin Ophthalmic need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Takaya T, Okamoto M, Yodoi K, et al: Torsades de Pointes with QT prolongation related to donepezil use. J Cardiol 2009; 54(3):507-511. PubMed
- Tanaka A, Koga S, & Hiramatsu Y: Donepezil-induced adverse side effects of cardiac rhythm: 2 cases report of atrioventricular block and Torsade de Pointes. Intern Med 2009; 48(14):1219-1223. PubMed
Keep reading about Donepezil
Keep reading about Gatifloxacin Ophthalmic
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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