Donepezil

105 interactions 6 explained in plain English

Also sold as: Adlarity Aricept

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Octreotide Injection Gatifloxacin Ophthalmic Estradiol Penicillin V Potassium Relugolix Ofloxacin Otic

104 Major 1 Moderate

All (105) Major (104) Moderate (1)

Major

Donepezil Acetaminophen And Codeine Capital® & Codeine Explained Reduced seizure threshold Details Donepezil Amitriptyline Elavil Explained Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Sertraline Explained An increased risk of QT interval prolongation Details Donepezil Buprenorphine Belbuca Explained Reduced seizure threshold and increased risk of QT prolongation Details Donepezil Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Donepezil Trospium / Xanomeline Cobenfy Explained Reduced seizure threshold Details Donepezil Alcaftadine Ophthalmic Lastacaft Reduced seizure threshold Details Donepezil Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Donepezil Ampicillin Amcill® Reduced seizure threshold Details Donepezil Ampicillin Injection Omnipen-N® Reduced seizure threshold Details Donepezil Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Aripiprazole Injection Abilify Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Asenapine Transdermal Patch Secuado Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Azithromycin AzaSite Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Abiraterone Abirtega Increased donepezil exposure Details Donepezil Aclidinium Oral Inhalation Tudorza Reduced seizure threshold Details Donepezil Alfuzosin UroXatral Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Anagrelide Agrylin Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Azelastine Nasal Spray Astelin® Nasal Spray Reduced seizure threshold Details Donepezil Azelastine Ophthalmic Optivar® Reduced seizure threshold Details Donepezil Atropine Ophthalmic Atropine Care 1% Reduced seizure threshold Details Donepezil Bedaquiline Sirturo Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Bepotastine Ophthalmic Bepreve Reduced seizure threshold Details Donepezil Butorphanol Injection Butorphic Reduced seizure threshold Details Donepezil Butorphanol Nasal Spray Stadol® NS Reduced seizure threshold Details Donepezil Chlorambucil Leukeran Reduced seizure threshold Details Donepezil Chloroquine Aralen® Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Cyclopentolate Ophthalmic Akpentolate® Reduced seizure threshold Details Donepezil Cyclosporine Injection Atopica Reduced seizure threshold Details Donepezil Cyclosporine Ophthalmic Cequa Reduced seizure threshold Details Donepezil Dasatinib Phyrago Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Degarelix Injection Firmagon Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Donepezil Diphenhydramine Injection Banophen Reduced seizure threshold Details Donepezil Diphenhydramine Topical Afterbite with Antihistamine Reduced seizure threshold Details Donepezil Disopyramide Norpace Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Dofetilide Tikosyn Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Dolasetron Anzemet Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Dolasetron Injection Anzemet Increased risk of QT-interval prolongation and torsade de pointes Details

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