Active Hexose Correlated Compound (ahcc) - Aricept (Donepezil) Interaction
Herbal: Active Hexose Correlated Compound (ahcc)
Drug: Donepezil
Brand names:
Aricept, Adlarity
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Nov 24, 2024
Interaction Details
Donepezil is classified as belonging to the following category: Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, AHCC might increase levels of drugs metabolized by CYP2D6.
In vitro studies suggest that AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Mach, C. M., Fugii, H., Wakame, K., and Smith, J. Evaluation of active hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy agents. J Soc Integr.Oncol. 2008;6(3):105-109.
- Smith, J. A., Hunter, R. J., Fujii, H., Wakame, K., and Wolf, J. Defining Synergistic Activity ofthe Combination of Active Hexose Correlated Compound (AHCC) with Liposomal Doxorubicin (Doxil). Presented at the 18th International Congress on Nutrition and
Active Hexose Correlated Compound (ahcc) Overview
Active Hexose Correlated Compound (AHCC) is a proprietary dietary supplement recognized for its potential immune-boosting properties, derived from the mycelia of Basidiomycota mushrooms, including shiitake (Lentinula edodes). Rich in alpha-glucans, AHCC is soluble in water and remains stable, with the additional advantage of enhanced intestinal solubility through micro-coating with candelilla wax. Within Traditional Chinese medicine (TCM), AHCC has found extensive application for various health conditions, particularly in addressing liver damage. Research and traditional usage suggest AHCC may support immune function and mitigate chemotherapy-related side effects, prompting further investigations into its mechanisms and potential benefits.
Donepezil Overview
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Donepezil is used to treat dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) in people who have Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Donepezil is in a class of medications called cholinesterase inhibitors. It improves mental function (such as memory, attention, the ability to interact with others, speak, think clearly, and perform regular daily activities) by increasing the amount of a certain naturally occurring substance in the brain. Donepezil may improve the ability to think and remember or slow the loss of these abilities in people who have AD. However, donepezil will not cure AD or prevent the loss of mental abilities at some time in the future.
Active Hexose Correlated Compound (ahcc) - More Interactions
Active Hexose Correlated Compound (ahcc) interacts with 301 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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