Donepezil

105 interactions 6 explained in plain English

Also sold as: Adlarity Aricept

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Octreotide Injection Gatifloxacin Ophthalmic Estradiol Penicillin V Potassium Relugolix Ofloxacin Otic

104 Major 1 Moderate

All (105) Major (104) Moderate (1)

Major

Donepezil Methylphenidate Adhansia XR® Reduced seizure threshold Details Donepezil Methylphenidate Transdermal Patch Daytrana Reduced seizure threshold Details Donepezil Metronidazole Flagyl Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Metronidazole Injection Flagyl Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Metronidazole Topical MetroCream® Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Metronidazole Vaginal MetroGel® Vaginal Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Morphine Injection Astramorph® PF Reduced seizure threshold Details Donepezil Moxifloxacin Avelox Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Moxifloxacin Injection Avelox Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Moxifloxacin Ophthalmic Moxeza® Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Nafarelin Nasal Spray Synarel Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Nafcillin Injection Unipen® Injection Decreased donepezil exposure; increased risk of seizures Details Donepezil Nalbuphine Injection Nubain® Reduced seizure threshold Details Donepezil Neostigmine Methylsulfate Bloxiverz Reduced seizure threshold Details Donepezil Octreotide Bynfezia Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Octreotide Injection Bynfezia Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Ofloxacin Floxin® Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Ofloxacin Ophthalmic Ocuflox Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Ofloxacin Otic Floxin® Otic Increased risk of QT-interval prolongation and torsade de pointes Details Donepezil Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Donepezil Olopatadine Pataday Reduced seizure threshold Details Donepezil Olopatadine Nasal Spray PATANASE Reduced seizure threshold Details Donepezil Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Donepezil Penicillin V Potassium Beepen-VK® Reduced seizure threshold Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.