Doravirine and Repotrectinib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Doravirine
Repotrectinib
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced doravirine exposure and reduced efficacy of doravirine
Interaction Deep Dive
Concomitant use of doravirine and moderate CYP3A inducers is not recommended as it may reduce doravirine exposure which may reduce efficacy of doravirine1.
Why it happens (mechanism)
Induction of CYP3A-mediated metabolism of doravirine
Literature reports
1 report — tap to read
a) In a drug interaction study, the first day following the cessation of efavirenz therapy efavirenz (600 mg once daily) and initiation of doravirine 100 mg once daily in 17 subjects reduced doravirine AUC and Cmax by 0.38-fold and 0.65-fold, respectively. Also, 14 days following the cessation of efavirenz therapy and initiation of doravirine 100 mg once daily resulted in reduced doravirine AUC and Cmax by 0.68-fold and 0.86-fold 1.
Common questions
Can I take Doravirine and Repotrectinib together?
Reduced doravirine exposure and reduced efficacy of doravirine Always confirm with your pharmacist or prescriber before making any change.
How serious is the Doravirine and Repotrectinib interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Doravirine or Repotrectinib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: IDVYNSO™ oral tablet, doravirine and islatravir oral tablet. Merck Sharp & Dohme LLC, Rahway, NJ, 2026. DailyMed
Keep reading about Doravirine
Keep reading about Repotrectinib
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