Doravirine

57 interactions 244 cited references

Also sold as: Pifeltro Pifeltro®

About Doravirine

Doravirine is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults who have not been treated with other HIV medications. It is also used to replace current medication therapy in certain people already taking HIV medications. Doravirine is in a class of medications called non… Read the full Doravirine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Encorafenib Apalutamide Fosphenytoin Enzalutamide Carbamazepine Ensitrelvir

16 Contraindicated 37 Major 4 Moderate

All (57) Contraindicated (16) Major (37) Moderate (4)

Contraindicated

Doravirine Apalutamide Erleada Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Carbamazepine Carbatrol Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Encorafenib Braftovi Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Doravirine Enzalutamide Xtandi Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Fosphenytoin Cerebyx Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Ivosidenib Tibsovo Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Lumacaftor Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Mitotane Lysodren Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Oxcarbazepine Oxtellar Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Phenobarbital Fidoquel Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Phenytoin Dilantin Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Primidone Mysoline Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Rifampin Rifadin Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Rifapentine Priftin Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine St John's Wort Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details

Major

Doravirine Cabotegravir Apretude Loss of virologic response and possible development of viral resistance Details Doravirine Atidarsagene Autotemcel Lenmeldy Interference with the manufacturing of atidarsagene autotemcel Details Doravirine Avacopan Tavneos Increased CYP3A4 substrate exposure Details Doravirine Bosentan Reduced doravirine exposure and reduced efficacy of doravirine Details Doravirine Cenobamate Xcopri Reduced doravirine exposure and reduced efficacy of doravirine Details Doravirine Clarithromycin Biaxin Increased exposure of CYP3A4 substrate and risk for toxicity Details Doravirine Conivaptan Vaprisol Increased CYP3A substrate exposure Details Doravirine Dabrafenib Tafinlar Reduced doravirine exposure and reduced efficacy of doravirine Details Doravirine Dipyrone Reduced doravirine exposure and reduced efficacy of doravirine Details Doravirine Efavirenz Decreased doravirine plasma concentration and reduced efficacy; increased risk of doravirine resistance Details Doravirine Elagolix Orilissa Reduced doravirine exposure and reduced efficacy of doravirine Details Doravirine Erythromycin Erythrocin Stearate Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse effects Details Doravirine Etravirine Intelence Decreased doravirine plasma concentration and reduced efficacy; increased risk of doravirine resistance Details Doravirine Etuvetidigene Autotemcel An increased risk of interference with the manufacturing of etuvetidigene autotemcel Details Doravirine Itraconazole Sporanox Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details Doravirine Lesinurad Reduced doravirine exposure and reduced efficacy of doravirine Details Doravirine Letermovir Prevymis Increased CYP3A substrate exposure Details Doravirine Lopinavir Reduced doravirine exposure and reduced efficacy of doravirine Details Doravirine Lorlatinib Lorbrena Reduced doravirine exposure and reduced efficacy of doravirine Details Doravirine Mifepristone Korlym Increased CYP3A4 substrate exposure Details Doravirine Mitapivat Aqvesme Reduced doravirine exposure and reduced efficacy of doravirine Details Doravirine Modafinil Provigil Reduced doravirine exposure and reduced efficacy of doravirine Details Doravirine Nafcillin Reduced doravirine exposure and reduced efficacy of doravirine Details Doravirine Nevirapine Viramune Decreased doravirine plasma concentration and reduced efficacy; increased risk of doravirine resistance Details

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