Doravirine

Name: Doravirine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

57 interactions 244 cited references

Also sold as: Pifeltro Pifeltro®

About Doravirine

Doravirine is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults who have not been treated with other HIV medications. It is also used to replace current medication therapy in certain people already taking HIV medications. Doravirine is in a class of medications called non… Read the full Doravirine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Encorafenib Apalutamide Fosphenytoin Enzalutamide Carbamazepine Ensitrelvir

16 Contraindicated 37 Major 4 Moderate

All (57) Contraindicated (16) Major (37) Moderate (4)

Moderate

Doravirine Artemether Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Doravirine Kratom Increased CYP3A substrate exposure Details Doravirine Mavacamten Camzyos Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Doravirine Rilzabrutinib Wayrilz Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.