Doravirine

57 interactions 244 cited references
Also sold as: Pifeltro Pifeltro®
About Doravirine

Doravirine is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults who have not been treated with other HIV medications. It is also used to replace current medication therapy in certain people already taking HIV medications. Doravirine is in a class of medications called non… Read the full Doravirine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Doravirine Apalutamide Erleada Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Carbamazepine Carbatrol Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Encorafenib Braftovi Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Doravirine Enzalutamide Xtandi Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Fosphenytoin Cerebyx Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Ivosidenib Tibsovo Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Lumacaftor Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Mitotane Lysodren Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Oxcarbazepine Oxtellar Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Phenobarbital Fidoquel Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Phenytoin Dilantin Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Primidone Mysoline Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Rifampin Rifadin Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine Rifapentine Priftin Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details Doravirine St John's Wort Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.