Dothiepin

32 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Meclofenamate Aspirin Meloxicam Injection Naproxen Clonidine Transdermal Patch Gatifloxacin Ophthalmic
27 Major 2 Moderate 3 Minor
All (32) Major (27) Moderate (2) Minor (3)

Major

Dothiepin Sertraline Explained Modest elevations in dothiepin serum levels or possible serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status c... Details Dothiepin Aspirin Acuprin® An increased risk of bleeding Details Dothiepin Aspirin Rectal Aspirin An increased risk of bleeding Details Dothiepin Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Dothiepin Clonidine Transdermal Patch Catapres Decreased antihypertensive effectiveness Details Dothiepin Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Dothiepin Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Dothiepin Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Dothiepin Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Dothiepin Etodolac Lodine An increased risk of bleeding Details Dothiepin Fenoprofen Fenopron An increased risk of bleeding Details Dothiepin Flurbiprofen Ansaid An increased risk of bleeding Details Dothiepin Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Dothiepin Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dothiepin Hydroxychloroquine Plaquenil An increased risk of seizures Details Dothiepin Ibuprofen Addaprin An increased risk of bleeding Details Dothiepin Ketoprofen Actron® An increased risk of bleeding Details Dothiepin Ketorolac Acular An increased risk of bleeding Details Dothiepin Ketorolac Injection Acular An increased risk of bleeding Details Dothiepin Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Dothiepin Ketorolac Ophthalmic Acular An increased risk of bleeding Details Dothiepin Meclofenamate Meclodium® An increased risk of bleeding Details Dothiepin Mefenamic Acid Ponstel® An increased risk of bleeding Details Dothiepin Meloxicam Alloxate An increased risk of bleeding Details Dothiepin Meloxicam Injection Alloxate An increased risk of bleeding Details Dothiepin Nabumetone Relafen An increased risk of bleeding Details Dothiepin Naproxen Aleve An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.