Doxifluridine

36 interactions 1 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Nateglinide Methotrexate Injection Leucovorin Injection Flurbiprofen Ophthalmic Erdafitinib Aficamten

34 Major 2 Minor

All (36) Major (34) Minor (2)

Major

Doxifluridine Abrocitinib Cibinqo Explained Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Allopurinol Aloprim Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Doxifluridine Allopurinol Injection Aloprim Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Doxifluridine Avatrombopag Doptelet Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Benznidazole Increased exposure of 5-fluorouracil Details Doxifluridine Aficamten Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Deuruxolitinib Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Diclofenac Ophthalmic Voltaren® Eye Drops Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Diclofenac Topical (Actinic Keratosis) Pennsaid Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Diclofenac Topical (Arthritis Pain) Pennsaid® Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Diclofenac Transdermal Patch Flector Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Dronabinol Marinol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Erdafitinib Balversa Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Flurbiprofen Ansaid Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Flurbiprofen Ophthalmic Ocufen Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Fluvastatin Lescol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Folic Acid Folacin Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Doxifluridine Glimepiride Amaryl Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Glipizide Glucotrol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Ibuprofen Addaprin Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Irbesartan Avapro Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Leucovorin Vykoura Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Doxifluridine Leucovorin Injection Vykoura Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Doxifluridine Losartan Arbli Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Macitentan Opsumit Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Meloxicam Alloxate Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Meloxicam Injection Alloxate Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Doxifluridine Methotrexate Jylamvo Increased 5-fluorouracil toxicity Details Doxifluridine Methotrexate Injection Abitrexate® Increased 5-fluorouracil toxicity Details Doxifluridine Metronidazole Flagyl Increased exposure of 5-fluorouracil Details Doxifluridine Metronidazole Injection Flagyl Increased exposure of 5-fluorouracil Details Doxifluridine Metronidazole Topical MetroCream® Increased exposure of 5-fluorouracil Details Doxifluridine Metronidazole Vaginal MetroGel® Vaginal Increased exposure of 5-fluorouracil Details Doxifluridine Nateglinide Starlix® Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details

Minor

Doxifluridine Gemcitabine Avgemsi Enhanced fluorouracil systemic exposure and possible toxicity Details Doxifluridine Gemcitabine Injection Avgemsi Enhanced fluorouracil systemic exposure and possible toxicity Details

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