Dronedarone and Cyclosporine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Dronedarone
Cyclosporine Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased dronedarone plasma concentrations
Interaction Deep Dive
Concomitant use of dronedarone (a CYP3A4 substrate) and ketoconazole (a strong CYP3A4 inhibitor) resulted in a 17-fold increase in dronedarone exposure and a 9-fold increase in dronedarone peak concentration, therefore, concomitant use of dronedarone and cycloSPORINE (a strong CYP3A4 inhibitor) is contraindicated1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated dronedarone metabolism
Common questions
Can I take Dronedarone and Cyclosporine Injection together?
Increased dronedarone plasma concentrations Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dronedarone and Cyclosporine Injection interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Dronedarone or Cyclosporine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: MULTAQ(R) oral tablets, dronedarone oral tablets. sanofi-aventis U.S. LLC, Bridgewater, NJ, 2011. DailyMed
Keep reading about Dronedarone
Keep reading about Cyclosporine Injection
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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