Dronedarone and Furosemide Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Dronedarone
Furosemide Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Risk of hypokalemia and hypomagnesemia
Interaction Deep Dive
Coadministration of dronedarone and a potassium-depleting diuretic (such as a loop, thiazide, or thiazide-related diuretic) may increase the risk of hypokalemia or hypomagnesemia. Serum potassium levels should be within the normal range prior to initiation of and throughout dronedarone therapy1.
Why it happens (mechanism)
Potassium and magnesium loss secondary to diuretics
Common questions
Can I take Dronedarone and Furosemide Injection together?
Risk of hypokalemia and hypomagnesemia Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dronedarone and Furosemide Injection interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Dronedarone or Furosemide Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: MULTAQ(R) oral tablets, dronedarone oral tablets. sanofi-aventis U.S. LLC, Bridgewater, NJ, 2009. DailyMed
Keep reading about Dronedarone
Keep reading about Furosemide Injection
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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