Dronedarone

146 interactions 12 explained in plain English
Also sold as: Multaq
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Dronedarone Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine exposure and increased or reduced active metabolite (morphine) exposure Details Dronedarone Simvastatin Flolipid Explained Increased simvastatin exposure and an increased risk of myopathy and rhabdomyolysis Details Dronedarone Acalabrutinib Calquence Increased acalabrutinib exposure and increased risk of toxicity Details Dronedarone Apixaban Eliquis Explained Increased apixaban exposure and increased risk of bleeding Details Dronedarone Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Dronedarone Atenolol Tenormin Explained Increased exposure to some beta blockers and increased incidence of bradycardia Details Dronedarone Avapritinib Ayvakit Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Dronedarone Azathioprine Azasan An increased risk of hepatotoxicity Details Dronedarone Betrixaban Bevyxxa® Increased betrixaban exposure and increased risk of bleeding Details Dronedarone Acebutolol Sectral® Increased exposure to some beta blockers and increased incidence of bradycardia Details Dronedarone Cariprazine Vraylar Explained Increased cariprazine and its major active metabolite (didesmethylcariprazine (DDCAR)) exposure Details Dronedarone Afatinib Gilotrif Increased exposure of afatinib Details Dronedarone Amlodipine Amvaz® Increased amLODIPine exposure and an increased risk of hypotension and edema Details Dronedarone Betaxolol Betoptic S Increased exposure to some beta blockers and increased incidence of bradycardia Details Dronedarone Betaxolol Ophthalmic Betoptic® Increased exposure to some beta blockers and increased incidence of bradycardia Details Dronedarone Bisoprolol Zebeta® Increased exposure to some beta blockers and increased incidence of bradycardia Details Dronedarone Bosutinib Bosulif Increased bosutinib exposure Details Dronedarone Brexpiprazole Rexulti Increased brexpiprazole exposure Details Dronedarone Brigatinib Alunbrig Increased brigatinib exposure Details Dronedarone Budesonide Entocort Increased budesonide exposure Details Dronedarone Budesonide Nasal Spray Rhinocort Increased budesonide exposure Details Dronedarone Budesonide Oral Inhalation Pulmicort Increased budesonide exposure Details Dronedarone Cobimetinib Cotellic Increased cobimetinib plasma concentrations Details Dronedarone Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Dronedarone Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Dronedarone Deflazacort Emflaza Increased exposure to active metabolite of deflazacort Details Dronedarone Dexamethasone Injection Decadron Reduced dronedarone exposure Details Dronedarone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced dronedarone exposure Details Dronedarone Digoxin Cardoxin® Increased digoxin exposure and increased conduction effects of dronedarone Details Dronedarone Dihydroergotamine Injection DHE-45® Injection Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dronedarone Dihydroergotamine Nasal Spray Migranal Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dronedarone Docetaxel Beizray An increased exposure to docetaxel Details Dronedarone Docetaxel Injection Beizray An increased exposure to docetaxel Details Dronedarone Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Dronedarone Edoxaban Savaysa Increased edoxaban exposure Details Dronedarone Elacestrant Orserdu Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Dronedarone Enasidenib Idhifa Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Dronedarone Esmolol Brevibloc Increased exposure to some beta blockers and increased incidence of bradycardia Details Dronedarone Everolimus Afinitor Increased everolimus exposure Details Dronedarone Fentanyl Transdermal Patch Duragesic® Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.