Echinacea

23 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Atogepant Cariprazine Amlodipine Lumateperone Nifedipine
5 Major 18 Moderate
All (23) Major (5) Moderate (18)

Major

Echinacea Atogepant Qulipta Reduced atogepant exposure Details Echinacea Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Echinacea Amlodipine Amvaz® Reduced amLODIPine exposure Details Echinacea Lumateperone Caplyta Reduced lumateperone exposure Details Echinacea Nifedipine Adalat® Reduced NIFEdipine exposure Details

Moderate

Echinacea Apixaban Eliquis Explained Increased exposure of apixaban Details Echinacea Azathioprine Azasan Decreased effectiveness of azathioprine Details Echinacea Cyclosporine Injection Atopica Decreased effectiveness of cycloSPORINE Details Echinacea Cyclosporine Ophthalmic Cequa Decreased effectiveness of cycloSPORINE Details Echinacea Cytarabine Cytosar-U® Decreased cytarabine efficacy in treatment of acute myeloid leukemia Details Echinacea Dabigatran Pradaxa® Increased risk of bleeding Details Echinacea Dabigatran Etexilate Increased risk of bleeding Details Echinacea Daunorubicin Cerubidine® Decreased DAUNOrubicin efficacy in treatment of acute myeloid leukemia Details Echinacea Deflazacort Emflaza Decreased effectiveness of corticosteroids Details Echinacea Dexamethasone Injection Decadron Decreased effectiveness of corticosteroids Details Echinacea Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Decreased effectiveness of corticosteroids Details Echinacea Edoxaban Savaysa Increased risk of bleeding Details Echinacea Fludrocortisone Acetate Florinef® Decreased effectiveness of corticosteroids Details Echinacea Hydrocortisone Ala-Cort Decreased effectiveness of corticosteroids Details Echinacea Hydrocortisone Injection A-Hydrocort® Decreased effectiveness of corticosteroids Details Echinacea Mercaptopurine Purinethol® Decreased effectiveness of azathioprine Details Echinacea Midazolam Nasal Spray Nayzilam Alterations in midazolam effectiveness Details Echinacea Midazolam Injection Nayzilam Alterations in midazolam effectiveness Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.