Elacestrant and Rosuvastatin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Rosuvastatin
Elacestrant
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased rosuvastatin exposure and an increased risk of rosuvastatin-related adverse effects
Interaction Deep Dive
Coadministration of elacestrant with rosuvastatin (a BCRP substrate) may increase the exposure of rosuvastatin, which may increase the incidence and severity of adverse reactions. For BCRP substrates where small concentration changes may lead to serious adverse reactions, reduce the dosage of BCRP substrates. In an interaction study, rosuvastatin Cmax increased by 1.5-fold and AUC increased by 1.2-fold following concomitant use of elacestrant single dose of 345 mg with rosuvastatin1.
Why it happens (mechanism)
Inhibition of BCRP-mediated efflux transport of rosuvastatin by elacestrant
Literature reports
1 report — tap to read
a) In an interaction study, rosuvastatin Cmax increased by 1.5-fold and AUC increased by 1.2-fold following concomitant use of elacestrant single dose of 345 mg with rosuvastatin (a BCRP substrate) 1.
Common questions
Can I take Elacestrant and Rosuvastatin together?
Increased rosuvastatin exposure and an increased risk of rosuvastatin-related adverse effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Elacestrant and Rosuvastatin interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Elacestrant or Rosuvastatin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: ORSERDU(TM) oral tablets, elacestrant oral tablets. Stemline Therapeutics (per FDA), New York, NY, 2023. DailyMed
Keep reading about Rosuvastatin
Keep reading about Elacestrant
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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