Rosuvastatin and Eluxadoline: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Rosuvastatin
Eluxadoline
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased rosuvastatin exposure
Interaction Deep Dive
Concomitant use of eluxadoline and rosuvastatin may increase exposure of rosuvastatin and increase the risk of myopathy or rhabdomyolysis. During drug interaction studies, coadministration of multiple doses of eluxadoline 100 mg twice daily and a single dose of rosuvastatin 20 mg resulted in a 40% and 18% increase in rosuvastatin AUC and Cmax compared with rosuvastatin alone. If concurrent use is required, use the lowest effective dose of rosuvastatin1.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) During drug interaction studies, coadministration of multiple doses of eluxadoline 100 mg twice daily and a single dose of rosuvastatin 20 mg resulted in a 40% and 18% increase in rosuvastatin AUC and Cmax compared with rosuvastatin alone 1.
Common questions
Can I take Rosuvastatin and Eluxadoline together?
Increased rosuvastatin exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Rosuvastatin and Eluxadoline interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Rosuvastatin or Eluxadoline need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VIBERZI oral tablets, eluxadoline oral tablets. Patheon Pharmaceuticals, Inc. (per Manufacturer), Cincinnati, OH, 2015. DailyMed
Keep reading about Rosuvastatin
Keep reading about Eluxadoline
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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