Eluxadoline and Cyclosporine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Cyclosporine
Eluxadoline
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased eluxadoline and/or cyclosporine exposure
Interaction Deep Dive
Concomitant use of eluxadoline with cyclosporine may increase the exposure of both eluxadoline and cyclosporine. During drug interaction studies, coadministration of single dose eluxadoline 100 mg and single dose cyclosporine 600 mg resulted in a 4.4- and 6.2-fold increase in eluxadoline AUC and Cmax compared with eluxadoline alone. If coadministered, reduce dose of eluxadoline to 75 mg twice daily and monitor for impaired mental or physical ability to perform potentially hazardous activities. Also monitor cyclosporine concentrations or other pharmacodynamic markers of drug effect when concomitant use with eluxadoline is initiated or discontinued1.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) During drug interaction studies, coadministration of single dose eluxadoline 100 mg and single dose cyclosporine 600 mg resulted in a 4.4- and 6.2-fold increase in eluxadoline AUC and Cmax compared with eluxadoline alone 1.
Common questions
Can I take Eluxadoline and Cyclosporine together?
Increased eluxadoline and/or cyclosporine exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Eluxadoline and Cyclosporine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Eluxadoline or Cyclosporine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VIBERZI oral tablets, eluxadoline oral tablets. Patheon Pharmaceuticals, Inc. (per Manufacturer), Cincinnati, OH, 2015. DailyMed
Keep reading about Cyclosporine
Keep reading about Eluxadoline
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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