Eluxadoline

26 interactions 15 cited references
Also sold as: Viberzi Viberzi®
About Eluxadoline

Eluxadoline is a mu-opioid receptor agonist used to treat irritable bowel syndrome with diarrhea in adults. Read the full Eluxadoline drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Eltrombopag Cyclosporine Voclosporin Elexacaftor Apalutamide Atazanavir
24 Major 2 Moderate
All (26) Major (24) Moderate (2)

Major

Eluxadoline Atogepant Qulipta Increased atogepant exposure Details Eluxadoline Cyclosporine Injection Atopica Increased eluxadoline and/or cyclosporine exposure Details Eluxadoline Cyclosporine Ophthalmic Cequa Increased eluxadoline and/or cyclosporine exposure Details Eluxadoline Darolutamide Nubeqa Increased eluxadoline exposure Details Eluxadoline Apalutamide Erleada Reduced OATP1B1 substrates exposure and reduced efficacy of OATP1B1 substrates Details Eluxadoline Atazanavir Reyataz Increased eluxadoline exposure Details Eluxadoline Atrasentan Increased atrasentan exposure and an increased risk of atrasentan-related adverse reactions Details Eluxadoline Cyclosporine Atopica Increased eluxadoline and/or cyclosporine exposure Details Eluxadoline Elexacaftor Increased OATP1B1 substrate exposure Details Eluxadoline Eltrombopag Alvaiz Increased eluxadoline exposure Details Eluxadoline Enasidenib Idhifa Increased eluxadoline exposure Details Eluxadoline Fostemsavir Rukobia Increased eluxadoline exposure Details Eluxadoline Gemfibrozil Lopid Increased eluxadoline exposure Details Eluxadoline Grazoprevir Increased eluxadoline exposure Details Eluxadoline Leniolisib Joenja Increased OATP1B1 substrate exposure Details Eluxadoline Lopinavir Increased eluxadoline exposure Details Eluxadoline Paritaprevir Increased eluxadoline exposure Details Eluxadoline Rifampin Rifadin Increased eluxadoline exposure Details Eluxadoline Ritonavir Norvir Increased eluxadoline exposure Details Eluxadoline Rosuvastatin Crestor Increased rosuvastatin exposure Details Eluxadoline Saquinavir Increased eluxadoline exposure Details Eluxadoline Tipranavir Aptivus Increased eluxadoline exposure Details Eluxadoline Velpatasvir Increased eluxadoline exposure Details Eluxadoline Voclosporin Lupkynis Increased OATP1B1 substrate exposure Details

Moderate

Eluxadoline Encorafenib Braftovi Increased OATP1B1 substrate exposure and increased risk of OATP1B1 substrate-related toxicities Details Eluxadoline Seladelpar Increased seladelpar exposure Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.