Drug Interaction Report

Elafibranor and Cholestyramine Resin: Interaction Details

A pharmacist-reviewed analysis of the Elafibranor and Cholestyramine Resin interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Cholestyramine Resin

Locholest® Locholest® Light Prevalite Prevalite® Questran Questran® Questran® Light
+

Elafibranor

Iqirvo
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 21 documented Elafibranor interactions, 19 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Reduced elafibranor exposure and reduced efficacy of elafibranor

Interaction Deep Dive

Coadministration of elafibranor and bile acid binding sequestrants may reduce elafibranor absorption and exposure and may reduce efficacy of elafibranor. Administer elafibranor at least 4 hours before or 4 hours after taking a bile acid binding sequestrant, or at as great an interval as possible1.

Why it happens (mechanism)

Reduced elafibranor absorption

Common questions

Can I take Elafibranor and Cholestyramine Resin together?

Reduced elafibranor exposure and reduced efficacy of elafibranor Always confirm with your pharmacist or prescriber before making any change.

How serious is the Elafibranor and Cholestyramine Resin interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Elafibranor or Cholestyramine Resin need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (1)

  1. Product Information: IQIRVO(R) oral tablets, elafibranor oral tablets. Ipsen Biopharmaceuticals, Inc. (Per FDA), Cambridge, MA, 2024. DailyMed
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Cholestyramine Resin

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All Cholestyramine Resin interactions (70) Cholestyramine Resin drug information
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Elafibranor

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All Elafibranor interactions (21)
Also serious with: Estradiol Nifedipine Colestipol Lovastatin

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