Elexacaftor

22 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abametapir Nateglinide Methotrexate Injection Lovastatin Eluxadoline Docetaxel
22 Major
All (22) Major (22)

Major

Elexacaftor Abametapir Explained Increased exposure of CYP3A4 substrate Details Elexacaftor Simvastatin Flolipid Explained Increased OATP1B1/OATP1B3 substrate exposure Details Elexacaftor Atogepant Qulipta Increased OATP1B1/OATP1B3 substrate exposure Details Elexacaftor Atorvastatin Atorvaliq Increased OATP1B1/OATP1B3 substrate exposure Details Elexacaftor Axitinib Inlyta Increased OATP1B1 substrate exposure Details Elexacaftor Cyclosporine Injection Atopica Increased elexacaftor exposure Details Elexacaftor Cyclosporine Ophthalmic Cequa Increased elexacaftor exposure Details Elexacaftor Docetaxel Beizray Increased OATP1B1/OATP1B3 substrate exposure Details Elexacaftor Docetaxel Injection Beizray Increased OATP1B1/OATP1B3 substrate exposure Details Elexacaftor Eluxadoline Viberzi Increased OATP1B1 substrate exposure Details Elexacaftor Exemestane Aromasin Increased OATP1B1 substrate exposure Details Elexacaftor Fexofenadine Allegra Increased OATP1B1/OATP1B3 substrate exposure Details Elexacaftor Fluvastatin Lescol Increased OATP1B1/OATP1B3 substrate exposure Details Elexacaftor Ketoconazole Topical Extina® Foam Increased elexacaftor exposure Details Elexacaftor Lefamulin Xenleta Increased elexacaftor exposure Details Elexacaftor Lenacapavir Injection Sunlenca Increased elexacaftor exposure Details Elexacaftor Lenacapavir Oral Sunlenca Increased elexacaftor exposure Details Elexacaftor Letermovir Injection Prevymis Increased elexacaftor exposure and an increased letermovir exposure Details Elexacaftor Lovastatin Altocor® Increased OATP1B1 substrate exposure Details Elexacaftor Methotrexate Jylamvo Increased OATP1B1 substrate exposure Details Elexacaftor Methotrexate Injection Abitrexate® Increased OATP1B1 substrate exposure Details Elexacaftor Nateglinide Starlix® Increased OATP1B1 substrate exposure Details

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