Enasidenib

168 interactions 116 cited references
Also sold as: Idhifa Idhifa®
About Enasidenib

Enasidenib is used to treat a certain type of acute myeloid leukemia (AML; a type of cancer that begins in the white blood cells) that has worsened or come back after treatment with other chemotherapy medications. Enasidenib is in a class of medications called an isocitrate dehydrongenase-2 (IDH2) inhibitor. It works b… Read the full Enasidenib drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Varicella Virus Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Colchicine Yellow Fever Vaccine Agomelatine Dengue Tetravalent Vaccine, Live
16 Contraindicated 146 Major 6 Moderate
All (168) Contraindicated (16) Major (146) Moderate (6)

Contraindicated

Enasidenib Colchicine Colcrys Increased colchicine exposure, an increased risk of colchicine toxicity, reduced colchicine and reduced efficacy of colchicine Details Enasidenib Agomelatine Increased agomelatine exposure Details Enasidenib Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Enasidenib Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Enasidenib Elagolix Orilissa Increased elagolix exposure and an increased risk of elagolix-related adverse reactions Details Enasidenib Fezolinetant Increased fezolinetant exposure Details Enasidenib Grazoprevir Increased grazoprevir exposure and an increased risk of ALT elevation Details Enasidenib Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Enasidenib Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Enasidenib Ranolazine Aspruzyo Increased or reduced ranolazine exposure Details Enasidenib Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Enasidenib Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Enasidenib Tizanidine Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, an increased drowsiness and psychomotor imp... Details Enasidenib Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Enasidenib Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Enasidenib Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.