Enasidenib and Agomelatine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Enasidenib
Agomelatine
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased agomelatine exposure
Interaction Deep Dive
Coadministration of agomelatine with fluvoxaMINE, a strong CYP1A2 inhibitor markedly inhibits the metabolism of agomelatine resulting in a 60-fold (range 12-412) increase of agomelatine exposure. Concomitant use of agomelatine (a CYP1A2 substrate) with a strong CYP1A2 inhibitor is contraindicated as it may increase the exposure of agomelatine12.
Why it happens (mechanism)
Inhibition of CYP1A2-mediated metabolism of agomelatine
Literature reports
1 report — tap to read
a) Coadministration of agomelatine with fluvoxaMINE, a strong CYP1A2 inhibitor markedly inhibits the metabolism of agomelatine resulting in a 60-fold (range 12-412) increase of agomelatine exposure 1.
Common questions
Can I take Enasidenib and Agomelatine together?
Increased agomelatine exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Enasidenib and Agomelatine interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Enasidenib or Agomelatine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: Thymanax oral film coated tablets, agomelatine oral film coated tablets. Servier (Ireland) Industries Ltd (per EMA), Arklow, Wicklow, Ireland, 2017.
- Product Information: Valdoxan oral film-coated tablets, agomelatine oral film-coated tablets. Les Laboratoires Servier (per EMA), Suresnes, France, 2012.
Keep reading about Enasidenib
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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