Entrectinib

Name: Entrectinib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

361 interactions 392 cited references

Also sold as: Rozlytrek Rozlytrek®

About Entrectinib

Entrectinib is used to treat a certain type of non-small cell lung cancer (NSCLC) in adults that has spread to other parts of the body. It is also used to treat certain types of solid tumors in adults and children 12 years of age and older that cannot be treated by surgery or that has spread to other parts of the body… Read the full Entrectinib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rubella Virus Vaccine, Live Piperaquine Posaconazole Saquinavir Ketoconazole Topical Pimozide

29 Contraindicated 325 Major 7 Moderate

All (361) Contraindicated (29) Major (325) Moderate (7)

Moderate

Entrectinib Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.