Entrectinib

361 interactions 392 cited references

Also sold as: Rozlytrek Rozlytrek®

About Entrectinib

Entrectinib is used to treat a certain type of non-small cell lung cancer (NSCLC) in adults that has spread to other parts of the body. It is also used to treat certain types of solid tumors in adults and children 12 years of age and older that cannot be treated by surgery or that has spread to other parts of the body… Read the full Entrectinib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rubella Virus Vaccine, Live Piperaquine Posaconazole Saquinavir Ketoconazole Topical Pimozide

29 Contraindicated 325 Major 7 Moderate

All (361) Contraindicated (29) Major (325) Moderate (7)

Contraindicated

Entrectinib Colchicine Colcrys Increased colchicine exposure and an increased risk of colchicine toxicity Details Entrectinib Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Entrectinib Bepridil An increased risk of QT interval prolongation Details Entrectinib Cisapride Propulsid® Increased risk of QT interval prolongation Details Entrectinib Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Entrectinib Dronedarone Multaq Increased risk of QT interval prolongation Details Entrectinib Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Entrectinib Fluconazole Diflucan Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Entrectinib Ketoconazole Extina Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Entrectinib Lefamulin Xenleta Increased lefamulin exposure, an increased risk of lefamulin-related adverse reactions, increased entrectinib exposure, an increas... Details Entrectinib Levoketoconazole Recorlev An increased risk of QT interval prolongation, an increased CYP3A4 substrate exposure and an increased risk of CYP3A substrate-rel... Details Entrectinib Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Entrectinib Mesoridazine An increased risk of QT interval prolongation Details Entrectinib Mifepristone Korlym Increased entrectinib exposure, increased miFEPRIStone exposure and an increased frequency or severity of adverse reactions includ... Details Entrectinib Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Entrectinib Pimozide Increased pimozide exposure and an increased risk of QT interval prolongation Details Entrectinib Piperaquine An increased risk of QT interval prolongation Details Entrectinib Posaconazole Noxafil Increased posaconazole exposure, an increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation and tors... Details Entrectinib Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Entrectinib Saquinavir An increased risk of QT interval prolongation Details Entrectinib Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Entrectinib Sparfloxacin An increased risk of QT interval prolongation Details Entrectinib Terfenadine An increased risk of QT interval prolongation Details Entrectinib Thioridazine An increased risk of QT interval prolongation Details Entrectinib Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Entrectinib Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Entrectinib Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details Entrectinib Ziprasidone Geodon An increased risk of QT interval prolongation Details Entrectinib Ketoconazole Topical Extina® Foam Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details

Major

Entrectinib Amitriptyline Elavil An increased risk of QT interval prolongation Details Entrectinib Sertraline An increased risk of QT interval prolongation Details Entrectinib Buprenorphine Belbuca An increased risk of QT interval prolongation Details Entrectinib Relugolix Orgovyx Increased relugolix exposure and an increased risk of QT interval prolongation Details Entrectinib Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Entrectinib Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Entrectinib Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Entrectinib Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Entrectinib Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Entrectinib Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Entrectinib Azithromycin AzaSite An increased risk of QT interval prolongation Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.