Ephedrine

Name: Ephedrine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

8 interactions

Read the full Ephedrine drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dihydroergotamine Injection Dihydroergotamine Nasal Spray Digoxin Dinoprostone Fentanyl Transdermal Patch Methylergonovine

2 Contraindicated 6 Major

All (8) Contraindicated (2) Major (6)

Contraindicated

Ephedrine Dihydroergotamine Injection DHE-45® Injection Increased risk of elevation of blood pressure Details Ephedrine Dihydroergotamine Nasal Spray Migranal Increased risk of elevation of blood pressure Details

Major

Ephedrine Digoxin Cardoxin® Increased risk of arrhythmias Details Ephedrine Dinoprostone Cervidil Additive hypertensive effects Details Ephedrine Fentanyl Transdermal Patch Duragesic® Reduced analgesic effect Details Ephedrine Methylergonovine Methergine Additive hypertensive effects Details Ephedrine Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details Ephedrine Oxytocin Injection Pitocin Additive hypertensive effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.