Eplerenone

Name: Eplerenone Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

55 interactions 4 explained in plain English

Also sold as: Inspra

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Perindopril Cyclosporine Injection Enalapril Fosinopril Ketoprofen

1 Contraindicated 48 Major 6 Moderate

All (55) Contraindicated (1) Major (48) Moderate (6)

Moderate

Eplerenone Trospium / Xanomeline Cobenfy Explained Increased oral sensitive CYP3A4 substrate exposure and an increased risk on severity and frequency of sensitive CYP3A4 substrate-r... Details Eplerenone Aliskiren Tekturna Hyperkalemia Details Eplerenone Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Eplerenone Irbesartan Avapro Increased risk of hyperkalemia Details Eplerenone Losartan Arbli Increased risk of hyperkalemia Details Eplerenone Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.