Eplerenone

55 interactions 4 explained in plain English

Also sold as: Inspra

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Perindopril Cyclosporine Injection Enalapril Fosinopril Ketoprofen

1 Contraindicated 48 Major 6 Moderate

All (55) Contraindicated (1) Major (48) Moderate (6)

Contraindicated

Eplerenone Ketoconazole Topical Extina® Foam Increased eplerenone exposure Details

Major

Eplerenone Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Eplerenone Lisinopril Prinivil Explained Increased risk of hyperkalemia Details Eplerenone Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Eplerenone Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Eplerenone Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Eplerenone Aspirin Acuprin® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Aspirin Rectal Aspirin Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Benazepril Lotensin Increased risk of hyperkalemia Details Eplerenone Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Captopril Capoten® Increased risk of hyperkalemia Details Eplerenone Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Eplerenone Cyclosporine Injection Atopica An increased risk of hyperkalemia Details Eplerenone Cyclosporine Ophthalmic Cequa An increased risk of hyperkalemia Details Eplerenone Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Enalapril Epaned Increased risk of hyperkalemia Details Eplerenone Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Eplerenone Etodolac Lodine Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Fenoprofen Fenopron Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Eplerenone Flurbiprofen Ansaid Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Fosinopril Monopril® Increased risk of hyperkalemia Details Eplerenone Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Eplerenone Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Eplerenone Ibuprofen Addaprin Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Ketoprofen Actron® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Ketorolac Acular Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Ketorolac Injection Acular Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Ketorolac Ophthalmic Acular Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Eplerenone Lenacapavir Injection Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Eplerenone Lenacapavir Oral Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Eplerenone Letermovir Injection Prevymis Increased eplerenone plasma concentrations Details Eplerenone Meclofenamate Meclodium® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Eplerenone Mefenamic Acid Ponstel® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.