Ergonovine

14 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dihydroergotamine Injection Dihydroergotamine Nasal Spray Dinoprostone Ketoconazole Topical Clotrimazole Clotrimazole Lozenge
4 Contraindicated 6 Major 4 Moderate
All (14) Contraindicated (4) Major (6) Moderate (4)

Contraindicated

Ergonovine Dihydroergotamine Injection DHE-45® Injection An increased risk of ergotism Details Ergonovine Dihydroergotamine Nasal Spray Migranal An increased risk of ergotism Details Ergonovine Dinoprostone Cervidil An increased risk of oxytocic toxicity (uterine hyperstimulation) Details Ergonovine Ketoconazole Topical Extina® Foam Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details

Major

Ergonovine Clotrimazole Aardora Anti-Fungal Maximum Strength Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergonovine Clotrimazole Lozenge Mycelex® Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergonovine Clotrimazole Topical Cruex Antifungal Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergonovine Clotrimazole Vaginal Gyne-Lotrimin 3® Cream Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergonovine Dopamine Additive hypertensive effects Details Ergonovine Droxidopa Northera Additive hypertensive effects Details

Moderate

Ergonovine Metronidazole Flagyl Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergonovine Metronidazole Injection Flagyl Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergonovine Metronidazole Topical MetroCream® Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergonovine Metronidazole Vaginal MetroGel® Vaginal Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details

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