Ergotamine

26 interactions 1 explained in plain English

Also sold as: Ergomar

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Letermovir Injection Dihydroergotamine Injection Ketoconazole Topical Dopamine Dihydroergotamine Nasal Spray Azithromycin

5 Contraindicated 16 Major 5 Moderate

All (26) Contraindicated (5) Major (16) Moderate (5)

Contraindicated

Ergotamine Dihydroergotamine Injection DHE-45® Injection An increased risk of ergotism Details Ergotamine Dihydroergotamine Nasal Spray Migranal An increased risk of ergotism Details Ergotamine Dopamine Peripheral vasoconstriction and gangrene Details Ergotamine Ketoconazole Topical Extina® Foam Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergotamine Letermovir Injection Prevymis Increased ergot alkaloids exposure and an increased risk of ergotism Details

Major

Ergotamine Abametapir Explained Increased exposure of CYP3A4 substrate Details Ergotamine Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Ergotamine Azithromycin AzaSite An increased risk of acute ergot toxicity (ergotism) Details Ergotamine Clotrimazole Aardora Anti-Fungal Maximum Strength Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergotamine Clotrimazole Lozenge Mycelex® Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergotamine Clotrimazole Topical Cruex Antifungal Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergotamine Clotrimazole Vaginal Gyne-Lotrimin 3® Cream Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergotamine Enasidenib Idhifa Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Ergotamine Lanreotide Injection Somatuline Altered exposure to CYP3A4 substrate Details Ergotamine Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Ergotamine Lenacapavir Injection Sunlenca Increased ergotamine exposure Details Ergotamine Lenacapavir Oral Sunlenca Increased ergotamine exposure Details Ergotamine Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Ergotamine Nevirapine Viramune Reduced ergotamine exposure Details Ergotamine Octreotide Bynfezia Increased exposure of CYP3A4 substrates with narrow therapeutic index Details Ergotamine Octreotide Injection Bynfezia Increased exposure of CYP3A4 substrates with narrow therapeutic index Details

Moderate

Ergotamine Metronidazole Flagyl Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergotamine Metronidazole Injection Flagyl Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergotamine Metronidazole Topical MetroCream® Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergotamine Metronidazole Vaginal MetroGel® Vaginal Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ergotamine Nadolol Corgard Peripheral ischemia Details

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