Esketamine

Name: Esketamine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

29 interactions 2 explained in plain English

Also sold as: Spravato

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Hydromorphone Rectal Buprenorphine Diphenhydramine Injection Methylergonovine Nifedipine Morphine Injection

25 Major 4 Moderate

All (29) Major (25) Moderate (4)

Moderate

Esketamine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Esketamine Dofetilide Tikosyn Increased dofetilide exposure Details Esketamine Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Esketamine Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.