Esketamine

29 interactions 2 explained in plain English
Also sold as: Spravato
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Hydromorphone Rectal Buprenorphine Diphenhydramine Injection Methylergonovine Nifedipine Morphine Injection
25 Major 4 Moderate
All (29) Major (25) Moderate (4)

Major

Esketamine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of sedation Details Esketamine Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Esketamine Aripiprazole Injection Abilify Increased risk of sedation Details Esketamine Asenapine Transdermal Patch Secuado Increased risk of sedation Details Esketamine Butorphanol Injection Butorphic Increased risk of sedation Details Esketamine Butorphanol Nasal Spray Stadol® NS Increased risk of sedation Details Esketamine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Esketamine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Esketamine Diazepam Nasal Spray Valtoco Increased risk of sedation Details Esketamine Diazepam Rectal Diastat Increased risk of sedation Details Esketamine Diphenhydramine Injection Banophen Increased risk of sedation Details Esketamine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of sedation Details Esketamine Fentanyl Transdermal Patch Duragesic® Increased risk of sedation Details Esketamine Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Esketamine Hydromorphone Injection Dilaudid Increased risk of sedation Details Esketamine Hydromorphone Rectal available generically Increased risk of sedation Details Esketamine Lacosamide Injection Motpoly An increased risk of CNS depression Details Esketamine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Esketamine Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Esketamine Methylergonovine Methergine Increased methylergonovine exposure Details Esketamine Midazolam Nasal Spray Nayzilam Increased risk of sedation Details Esketamine Midazolam Injection Nayzilam Increased risk of sedation Details Esketamine Morphine Injection Astramorph® PF Increased risk of sedation Details Esketamine Nalbuphine Injection Nubain® Increased risk of sedation Details Esketamine Nifedipine Adalat® Increased NIFEdipine exposure Details

Moderate

Esketamine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Esketamine Dofetilide Tikosyn Increased dofetilide exposure Details Esketamine Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Esketamine Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.