Esmolol

191 interactions 1 explained in plain English 406 cited references

Also sold as: Brevibloc

Read the full Esmolol drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Olodaterol Oral Inhalation Clonidine Transdermal Patch Verapamil Terbutaline Taletrectinib Siponimod

36 Major 155 Moderate

All (191) Major (36) Moderate (155)

Moderate

Esmolol Dipyrone Reduced antihypertensive effect Details Esmolol Droxicam Reduced antihypertensive effect Details Esmolol Dulaglutide Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Etodolac Lodine Reduced antihypertensive effect Details Esmolol Etofenamate Reduced antihypertensive effect Details Esmolol Etoricoxib Reduced antihypertensive effect Details Esmolol Etrasimod Velsipity May increase the risk of transient decrease in heart rate Details Esmolol Exenatide Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Felbinac Reduced antihypertensive effect Details Esmolol Fenoprofen Fenopron Reduced antihypertensive effect Details Esmolol Fepradinol Reduced antihypertensive effect Details Esmolol Feprazone Reduced antihypertensive effect Details Esmolol Floctafenine Reduced antihypertensive effect Details Esmolol Flufenamic Acid Reduced antihypertensive effect Details Esmolol Flurbiprofen Ansaid Reduced antihypertensive effect Details Esmolol Glimepiride Amaryl Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Glipizide Glucotrol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Glucagon A transient increase in pulse and blood pressure Details Esmolol Glyburide DiaBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Ibuprofen Addaprin Reduced antihypertensive effect Details Esmolol Indomethacin Indocin Reduced antihypertensive effect Details Esmolol Insulin Aspart, Recombinant Fiasp Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Insulin Degludec Tresiba Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Insulin Detemir Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Insulin Glargine, Recombinant Basaglar Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Insulin Glulisine Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Insulin Human Inhaled Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Insulin Human Isophane (Nph) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Insulin Human Regular Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Insulin Lispro, Recombinant Admelog Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Ketoprofen Actron® Reduced antihypertensive effect Details Esmolol Ketorolac Acular Reduced antihypertensive effect Details Esmolol Lidoflazine Hypotension, bradycardia, and AV conduction disturbances Details Esmolol Linagliptin Tradjenta Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Liraglutide Saxenda Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Lixisenatide Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Lornoxicam Reduced antihypertensive effect Details Esmolol Loxoprofen Reduced antihypertensive effect Details Esmolol Lumiracoxib Reduced antihypertensive effect Details Esmolol Ma Huang Reduced hypotensive effect of beta-adrenergic blockers Details

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