Drug Interaction Report

Estradiol Topical and Temazepam: Interaction Details

A pharmacist-reviewed analysis of the Estradiol Topical and Temazepam interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Temazepam

Restoril
+

Estradiol Topical

Divigel Divigel® Elestrin Elestrin® Estrasorb® Estrogel EstroGel® Evamist®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 194 documented Estradiol Topical interactions, 28 are rated moderate — including this one.
Onset
delayed
Evidence
probable
Severity
Moderate

What happens

Reduced temazepam exposure and reduced efficacy of temazepam

Interaction Deep Dive

Combination contraceptives may stimulate the glucuronide conjugation of temazepam24, may increase the clearance of temazepam 3 and decrease plasma concentrations of temazepam 21.

Why it happens (mechanism)

Increased temazepam clearance; induction of temazepam glucuronidation

Literature reports

1 report — tap to read

a) Concomitant oral contraceptive and temazepam therapy has been reported to alter the metabolism of temazepam. In one study, low-dose estrogen oral contraceptives significantly decreased the AUC and increased the elimination rate of temazepam following single-dose therapy (30 mg). Based on these data, normal therapeutic doses of temazepam may be less effective in women using oral contraceptives 4.

Common questions

Can I take Estradiol Topical and Temazepam together?

Reduced temazepam exposure and reduced efficacy of temazepam Always confirm with your pharmacist or prescriber before making any change.

How serious is the Estradiol Topical and Temazepam interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "delayed". Effects tend to build up gradually over days to weeks.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Estradiol Topical or Temazepam need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (4)

  1. Product Information: LOESTRIN(R) 24 Fe oral tablets, norethindrone acetate ethinyl estradiol oral tablets, ferrous fumarate oral tablets. Teva Pharmaceuticals USA Inc (per FDA), Parsippany, NJ, 2023. DailyMed
  2. Product Information: ALESSE(R) 28 oral tablets, levonorgestrel ethinyl estradiol oral tablets. Cadence Health (per FDA), New York, NY, 2024.
  3. Product Information: YAZ(R) oral tablets, drospirenone, ethinyl estradiol oral tablets. Berlex,Inc, Montville, NJ, 2006. DailyMed
  4. Stoehr GP, Kroboth PD, Juhl RP, et al: Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics. Clin Pharmacol Ther 1984; 36:683-690. PubMed
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Temazepam

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Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Temazepam + 1,4-butanediol Activated Charcoal Beer Gamma-hydroxybutyrate (ghb) Grapefruit Kava L-tryptophan St. John's Wort + 189 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.