Estradiol Topical

194 interactions 765 cited references

Also sold as: Divigel Divigel® Elestrin Elestrin® Estrasorb® Estrogel EstroGel® Evamist®

About Estradiol Topical

Estradiol topical gel and emulsion (lotion type mixture) are used to treat and prevent hot flushes (hot flashes; sudden strong feelings of heat and sweating) in women who are experiencing menopause (change of life; the end of monthly menstrual periods). Estradiol topical gel is also used to treat vaginal dryness, itchi… Read the full Estradiol Topical drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Tranexamic Acid Fezolinetant Ensitrelvir Warfarin Ivosidenib Itraconazole

3 Contraindicated 151 Major 28 Moderate 12 Minor

All (194) Contraindicated (3) Major (151) Moderate (28) Minor (12)

Contraindicated

Estradiol Topical Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Estradiol Topical Fezolinetant Increased fezolinetant exposure Details Estradiol Topical Tranexamic Acid Cyklokapron An increased risk of thrombotic events Details

Major

Estradiol Topical Abametapir Increased exposure of CYP3A4 substrate Details Estradiol Topical Alfentanil Increased ALfentanil exposure, an increased risk of ALfentanil-related adverse reactions and/or prolonged effects, which may exace... Details Estradiol Topical Amifampridine Increased risk of seizures Details Estradiol Topical Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Estradiol Topical Ampicillin Amcill® Decreased contraceptive effectiveness Details Estradiol Topical Amprenavir Reduced amprenavir exposure, altered hormonal levels, loss of contraceptive efficacy, and an increased risk of liver enzyme elevat... Details Estradiol Topical Apalutamide Erleada Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Estradiol Topical Aprepitant Aponvie Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Estradiol Topical Armodafinil Nuvigil Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Estradiol Topical Avacopan Tavneos Increased CYP3A4 substrate exposure Details Estradiol Topical Bacampicillin Decreased contraceptive effectiveness Details Estradiol Topical Belzutifan Welireg An increased belzutifan exposure, an increased risk of belzutifan-related adverse effects, reduced hormonal contraceptives exposur... Details Estradiol Topical Betamethasone Betavet Increased corticosteroid effects Details Estradiol Topical Bexarotene Targretin Decreased contraceptive effectiveness Details Estradiol Topical Bosentan Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleeding... Details Estradiol Topical Bupropion Aplenzin Increased risk of seizures Details Estradiol Topical Carbamazepine Carbatrol Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Estradiol Topical Carbenicillin Decreased contraceptive effectiveness Details Estradiol Topical Cefaclor Ceclor® Decreased contraceptive effectiveness Details Estradiol Topical Cefadroxil Duricef® Decreased contraceptive effectiveness Details Estradiol Topical Cefdinir Omnicef® Decreased contraceptive effectiveness Details Estradiol Topical Cefditoren Spectracef® Decreased contraceptive effectiveness Details Estradiol Topical Cefixime Suprax Decreased contraceptive effectiveness Details Estradiol Topical Cefpodoxime Banan® Decreased contraceptive effectiveness Details Estradiol Topical Cefprozil Cefzil® Decreased contraceptive effectiveness Details Estradiol Topical Ceftazidime Decreased contraceptive effectiveness Details Estradiol Topical Ceftibuten Cedax® Decreased contraceptive effectiveness Details Estradiol Topical Cefuroxime Ceftin® Decreased contraceptive effectiveness Details Estradiol Topical Cenobamate Xcopri Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Estradiol Topical Ceritinib Zykadia Increased CYP3A substrate exposure Details Estradiol Topical Clarithromycin Biaxin Increased exposure of CYP3A4 substrate and risk for toxicity Details Estradiol Topical Clobazam Onfi Decreased contraceptive effectiveness Details Estradiol Topical Cloxacillin Decreased contraceptive effectiveness Details Estradiol Topical Clozapine Clozaril Increased clozapine exposure and increased risk of adverse effects Details Estradiol Topical Colesevelam Welchol Decreased contraceptive effectiveness Details Estradiol Topical Conivaptan Vaprisol Increased CYP3A substrate exposure Details Estradiol Topical Cosyntropin Increased cortisol exposure Details

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