Temazepam

27 interactions 2 explained in plain English
Also sold as: Restoril
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Diazepam Nasal Spray Lacosamide Injection Midazolam Nasal Spray Butorphanol Injection Butorphanol Nasal Spray Nalbuphine Injection
21 Major 6 Moderate
All (27) Major (21) Moderate (6)

Major

Temazepam Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Temazepam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Temazepam Aripiprazole Injection Abilify An increased risk of sedation and orthostatic hypotension Details Temazepam Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Temazepam Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Temazepam Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Temazepam Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Temazepam Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Temazepam Diazepam Rectal Diastat Increased risk of CNS depression Details Temazepam Esketamine Nasal Spray Spravato Increased risk of sedation Details Temazepam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Temazepam Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Temazepam Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Temazepam Lacosamide Injection Motpoly An increased risk of CNS depression Details Temazepam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Temazepam Metoclopramide Injection Gimoti Increased risk of CNS depression Details Temazepam Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Temazepam Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Temazepam Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Temazepam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Temazepam Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Temazepam Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Temazepam Estradiol Delestrogen Reduced temazepam exposure and reduced efficacy of temazepam Details Temazepam Estradiol Topical Divigel Reduced temazepam exposure and reduced efficacy of temazepam Details Temazepam Estradiol Transdermal Patch Alora® Reduced temazepam exposure and reduced efficacy of temazepam Details Temazepam Levonorgestrel After banger Reduced temazepam exposure and reduced efficacy of temazepam Details Temazepam Levonorgestrel Intrauterine System Kyleena Reduced temazepam exposure and reduced efficacy of temazepam Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.