Estramustine

34 interactions 318 cited references
Also sold as: Emcyt Emcyt®
About Estramustine

Estramustine is used to treat prostate cancer that has worsened or has spread to other parts of the body. Estramustine is in a class of medications called antimicrotubule agents. It works by stopping the growth and spread of cancer cells. Read the full Estramustine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Yellow Fever Vaccine Smallpox Monkeypox Vaccine Rubella Virus Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live
9 Contraindicated 19 Major 6 Moderate
All (34) Contraindicated (9) Major (19) Moderate (6)

Contraindicated

Estramustine Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Estramustine Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Estramustine Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Estramustine Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Estramustine Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Estramustine Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Estramustine Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Estramustine Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Estramustine Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Estramustine Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Estramustine Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Estramustine Amifampridine Increased risk of seizures Details Estramustine Bupropion Aplenzin Increased risk of seizures Details Estramustine Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Estramustine Clomipramine Anafranil Increased risk of seizures Details Estramustine Cosyntropin Increased cortisol exposure Details Estramustine Donepezil Adlarity Reduced seizure threshold Details Estramustine Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Estramustine Fosphenytoin Cerebyx An increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure, an increased risk of phenytoin or fosphenytoin toxicity (a... Details Estramustine Hydroxychloroquine Plaquenil An increased risk of seizures Details Estramustine Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Estramustine Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Estramustine Insulin Glargine, Recombinant Basaglar Reduced blood glucose lowering effect of insulin Details Estramustine Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Estramustine Phenytoin Dilantin An increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure, an increased risk of phenytoin or fosphenytoin toxicity (a... Details Estramustine Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Estramustine Somatrogon-Ghla Reduced somatrogon-ghla efficacy Details Estramustine Tramadol ConZip An increased risk of seizure Details

Moderate

Estramustine Insulin Afrezza May decrease blood glucose lowering effect of insulin Details Estramustine Insulin Lispro, Recombinant Admelog May decrease blood glucose lowering effect of insulin lispro Details Estramustine Levothyroxine Ermeza Reduced serum-free thyroxine exposure Details Estramustine Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Estramustine Somapacitan-Beco Decreased somapacitan-beco efficacy Details Estramustine Somatropin Accretropin® Decreased somatropin efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.