Etodolac

290 interactions 321 cited references

Also sold as: Lodine Lodine® Lodine® XL

About Etodolac

Etodolac is an NSAID used to relieve pain, swelling, and stiffness from osteoarthritis, rheumatoid arthritis, and other causes. Read the full Etodolac drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Opipramol Olsalazine

4 Contraindicated 227 Major 59 Moderate

All (290) Contraindicated (4) Major (227) Moderate (59)

Major

Etodolac Amtolmetin Guacil Increased risk of bleeding Details Etodolac Ardeparin An increased risk of bleeding Details Etodolac Argatroban An increased risk of bleeding Details Etodolac Balsalazide Colazal Increased risk of bleeding Details Etodolac Bemetizide Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Bemiparin An increased risk of bleeding Details Etodolac Bendroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Benzthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Bismuth Subsalicylate Bismarex Increased risk of bleeding Details Etodolac Bivalirudin Angiomax An increased risk of bleeding Details Etodolac Bromfenac Bromsite Increased risk of bleeding Details Etodolac Bufexamac Increased risk of bleeding Details Etodolac Bumetanide Bumex Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Cangrelor Kengreal An increased risk of bleeding Details Etodolac Celecoxib Celebrex An increased risk of GI toxicity and an increased risk of bleeding Details Etodolac Certoparin An increased risk of bleeding Details Etodolac Chlorothiazide Diuril Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Chlorthalidone Hemiclor Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Choline Magnesium Trisalicylate Trilisate® Increased risk of bleeding Details Etodolac Choline Salicylate Increased risk of bleeding Details Etodolac Cilostazol Pletal® An increased risk of bleeding Details Etodolac Citalopram Celexa An increased risk of bleeding Details Etodolac Clomipramine Anafranil An increased risk of bleeding Details Etodolac Clonixin Increased risk of bleeding Details Etodolac Clopamide Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Cyclopenthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Cyclosporine Atopica An increased risk of cycloSPORINE nephrotoxicity Details Etodolac Cyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Dalteparin Fragmin An increased risk of bleeding Details Etodolac Danaparoid An increased risk of bleeding Details Etodolac Desipramine Norpramin An increased risk of bleeding Details Etodolac Desirudin Iprivask An increased risk of bleeding Details Etodolac Desvenlafaxine Pristiq An increased risk of bleeding Details Etodolac Dexamethasone Increased risk of gastrointestinal ulcer or bleeding Details Etodolac Dexibuprofen Increased risk of bleeding Details Etodolac Dexketoprofen Increased risk of bleeding Details Etodolac Diazoxide Proglycem Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Dibenzepin An increased risk of bleeding Details Etodolac Diclofenac Aleve Arthritis Pain Increased risk of bleeding Details Etodolac Diflunisal Dolobid Increased risk of bleeding Details

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