Etodolac

290 interactions 321 cited references

Also sold as: Lodine Lodine® Lodine® XL

About Etodolac

Etodolac is an NSAID used to relieve pain, swelling, and stiffness from osteoarthritis, rheumatoid arthritis, and other causes. Read the full Etodolac drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Opipramol Olsalazine

4 Contraindicated 227 Major 59 Moderate

All (290) Contraindicated (4) Major (227) Moderate (59)

Moderate

Etodolac Lisinopril Prinivil Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Atenolol Tenormin Reduced antihypertensive effect Details Etodolac Acebutolol Sectral® Reduced antihypertensive effect Details Etodolac Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Betaxolol Betoptic S Reduced antihypertensive effect Details Etodolac Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Etodolac Bisoprolol Zebeta® Reduced antihypertensive effect Details Etodolac Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Etodolac Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Esmolol Brevibloc Reduced antihypertensive effect Details Etodolac Anisindione An increased risk of bleeding Details Etodolac Azilsartan Medoxomil Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Candesartan Atacand Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Carteolol Reduced antihypertensive effect Details Etodolac Carvedilol Coreg Reduced antihypertensive effect Details Etodolac Celiprolol Reduced antihypertensive effect Details Etodolac Ciprofloxacin An increased risk of convulsions Details Etodolac Desmopressin DDAVP Increased risk of water intoxication with hyponatremia Details Etodolac Dicumarol An increased risk of bleeding Details Etodolac Enalaprilat Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Ginkgo An increased risk of bleeding Details Etodolac Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Labetalol Normodyne® Reduced antihypertensive effect Details Etodolac Levobunolol Betagan Reduced antihypertensive effect Details Etodolac Levofloxacin Levaquin An increased risk of seizures Details Etodolac L-Methylfolate Decreased l-methylfolate efficacy Details Etodolac Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Ma Huang Increased risk of developing gastric mucosal lesions Details Etodolac Metipranolol Reduced antihypertensive effect Details Etodolac Metoprolol Kapspargo Reduced antihypertensive effect Details Etodolac Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Nadolol Corgard Reduced antihypertensive effect Details Etodolac Nebivolol Bystolic Reduced antihypertensive effect Details Etodolac Norfloxacin An increased risk of seizures Details Etodolac Ofloxacin Floxin® An increased risk of seizures Details Etodolac Olmesartan Benicar Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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