Etodolac

290 interactions 321 cited references
Also sold as: Lodine Lodine® Lodine® XL
About Etodolac

Etodolac is an NSAID used to relieve pain, swelling, and stiffness from osteoarthritis, rheumatoid arthritis, and other causes. Read the full Etodolac drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Opipramol Olsalazine
4 Contraindicated 227 Major 59 Moderate
All (290) Contraindicated (4) Major (227) Moderate (59)

Contraindicated

Etodolac Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Etodolac Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Etodolac Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Etodolac Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Etodolac Amitriptyline Elavil An increased risk of bleeding Details Etodolac Sertraline An increased risk of bleeding Details Etodolac Apixaban Eliquis An increased risk of bleeding Details Etodolac Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Etodolac Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Etodolac Azathioprine Azasan An increased risk of hepatotoxicity Details Etodolac Betrixaban Bevyxxa® An increased risk of bleeding Details Etodolac Anagrelide Agrylin An increased risk of bleeding Details Etodolac Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Etodolac Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Etodolac Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Etodolac Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Etodolac Clopidogrel Plavix An increased risk of bleeding Details Etodolac Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Etodolac Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Etodolac Dabigatran Pradaxa® An increased risk of bleeding Details Etodolac Dabigatran Etexilate An increased risk of bleeding Details Etodolac Dalteparin Injection Fragmin An increased risk of bleeding Details Etodolac Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Etodolac Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Etodolac Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Etodolac Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Etodolac Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Etodolac Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Etodolac Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Etodolac Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Etodolac Dipyridamole Permole® An increased risk of bleeding Details Etodolac Edoxaban Savaysa An increased risk of bleeding Details Etodolac Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Etodolac Enoxaparin Lovenox An increased risk of bleeding Details Etodolac Enoxaparin Injection Lovenox An increased risk of bleeding Details Etodolac Epoprostenol Flolan An increased risk of bleeding Details Etodolac Abciximab An increased risk of bleeding Details Etodolac Aceclofenac Increased risk of bleeding Details Etodolac Acemetacin Increased risk of bleeding Details Etodolac Acenocoumarol An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.