Etodolac

290 interactions 321 cited references
Also sold as: Lodine Lodine® Lodine® XL
About Etodolac

Etodolac is an NSAID used to relieve pain, swelling, and stiffness from osteoarthritis, rheumatoid arthritis, and other causes. Read the full Etodolac drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Opipramol Olsalazine
4 Contraindicated 227 Major 59 Moderate
All (290) Contraindicated (4) Major (227) Moderate (59)

Moderate

Etodolac Oxprenolol Reduced antihypertensive effect Details Etodolac Penbutolol Levatol® Reduced antihypertensive effect Details Etodolac Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Pindolol Visken® Reduced antihypertensive effect Details Etodolac Pralatrexate Increased pralatrexate exposure Details Etodolac Propranolol Hemangeol Reduced antihypertensive effect Details Etodolac Quinapril Accupril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Ramipril Altace Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Sotalol Betapace Reduced antihypertensive effect Details Etodolac Sparsentan Filspari An increased risk of worsening of renal function Details Etodolac Spirapril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Telmisartan Micardis Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Timolol Betimol Reduced antihypertensive effect Details Etodolac Trandolapril Mavik® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Valsartan Diovan Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Etodolac Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Etodolac Levofloxacin Injection Levaquin An increased risk of seizures Details Etodolac Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Etodolac Ofloxacin Otic Floxin® Otic An increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.