Etodolac

290 interactions 321 cited references

Also sold as: Lodine Lodine® Lodine® XL

About Etodolac

Etodolac is an NSAID used to relieve pain, swelling, and stiffness from osteoarthritis, rheumatoid arthritis, and other causes. Read the full Etodolac drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Opipramol Olsalazine

4 Contraindicated 227 Major 59 Moderate

All (290) Contraindicated (4) Major (227) Moderate (59)

Major

Etodolac Dipyrone Increased risk of bleeding Details Etodolac Dothiepin An increased risk of bleeding Details Etodolac Doxepin Prudoxin An increased risk of bleeding Details Etodolac Droxicam Increased risk of bleeding Details Etodolac Duloxetine An increased risk of bleeding Details Etodolac Eplerenone Inspra Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Etodolac Eptifibatide An increased risk of bleeding Details Etodolac Escitalopram Lexapro An increased risk of bleeding Details Etodolac Ethacrynic Acid Edecrin Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Etofenamate Increased risk of bleeding Details Etodolac Etoricoxib Increased risk of bleeding Details Etodolac Etozolin Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Felbinac Increased risk of bleeding Details Etodolac Fenoprofen Fenopron Increased risk of bleeding Details Etodolac Fepradinol Increased risk of bleeding Details Etodolac Feprazone Increased risk of bleeding Details Etodolac Feverfew Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects) Details Etodolac Floctafenine Increased risk of bleeding Details Etodolac Flufenamic Acid Increased risk of bleeding Details Etodolac Fluoxetine RECONCILE An increased risk of bleeding Details Etodolac Flurbiprofen Ansaid Increased risk of bleeding Details Etodolac Fluvoxamine An increased risk of bleeding Details Etodolac Fondaparinux Arixtra An increased risk of bleeding Details Etodolac Furosemide Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Gossypol Increased risk of adverse gastrointestinal effects Details Etodolac Heparin An increased risk of bleeding Details Etodolac Hydrochlorothiazide Inzirqo Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Etodolac Hydroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Ibuprofen Addaprin Increased risk of bleeding Details Etodolac Iloprost Aurlumyn An increased risk of bleeding Details Etodolac Imipramine An increased risk of bleeding Details Etodolac Indapamide Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Inotersen Increased risk of bleeding Details Etodolac Ketoprofen Actron® Increased risk of bleeding Details Etodolac Lepirudin An increased risk of bleeding Details Etodolac Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Etodolac Levomilnacipran An increased risk of bleeding Details Etodolac Lithium Increased lithium exposure and an increased risk of lithium toxicity Details Etodolac Lofepramine An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.