Etodolac

290 interactions 321 cited references

Also sold as: Lodine Lodine® Lodine® XL

About Etodolac

Etodolac is an NSAID used to relieve pain, swelling, and stiffness from osteoarthritis, rheumatoid arthritis, and other causes. Read the full Etodolac drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Opipramol Olsalazine

4 Contraindicated 227 Major 59 Moderate

All (290) Contraindicated (4) Major (227) Moderate (59)

Major

Etodolac Lornoxicam Increased risk of bleeding Details Etodolac Loxoprofen Increased risk of bleeding Details Etodolac Lumiracoxib Increased risk of bleeding Details Etodolac Magnesium Salicylate Increased risk of bleeding Details Etodolac Meadowsweet Increased risk of bleeding Details Etodolac Meclofenamate Meclodium® Increased risk of bleeding Details Etodolac Mefenamic Acid Ponstel® Increased risk of bleeding Details Etodolac Melitracen An increased risk of bleeding Details Etodolac Meloxicam Alloxate Increased risk of bleeding Details Etodolac Melphalan Alkeran An increased risk of bleeding Details Etodolac Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Etodolac Mesalamine Apriso Increased risk of bleeding Details Etodolac Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Etodolac Methyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Methylprednisolone Depo-Medrol Increased risk of gastrointestinal ulcer or bleeding Details Etodolac Metolazone Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Milnacipran Savella An increased risk of bleeding Details Etodolac Morniflumate Increased risk of bleeding Details Etodolac Nabumetone Relafen Increased risk of bleeding Details Etodolac Nadroparin An increased risk of bleeding Details Etodolac Naproxen Aleve Increased risk of bleeding Details Etodolac Nefazodone An increased risk of bleeding Details Etodolac Nepafenac Ilevro Increased risk of bleeding Details Etodolac Niflumic Acid Increased risk of bleeding Details Etodolac Nimesulide Increased risk of bleeding Details Etodolac Nimesulide Beta Cyclodextrin Increased risk of bleeding Details Etodolac Nortriptyline An increased risk of bleeding Details Etodolac Olsalazine Dipentum Increased risk of bleeding Details Etodolac Opipramol An increased risk of bleeding Details Etodolac Oxaprozin Coxanto Increased risk of bleeding Details Etodolac Oxyphenbutazone Increased risk of bleeding Details Etodolac Parecoxib Increased risk of bleeding Details Etodolac Parnaparin An increased risk of bleeding Details Etodolac Paroxetine Paxil An increased risk of bleeding Details Etodolac Pemetrexed Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Etodolac Pentosan Polysulfate Sodium An increased risk of bleeding Details Etodolac Pentoxifylline Pentoxil® An increased risk of bleeding Details Etodolac Phenindione An increased risk of bleeding Details Etodolac Phenprocoumon An increased risk of bleeding Details Etodolac Phenylbutazone Equi-Phar Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.