Etodolac

290 interactions 321 cited references

Also sold as: Lodine Lodine® Lodine® XL

About Etodolac

Etodolac is an NSAID used to relieve pain, swelling, and stiffness from osteoarthritis, rheumatoid arthritis, and other causes. Read the full Etodolac drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Opipramol Olsalazine

4 Contraindicated 227 Major 59 Moderate

All (290) Contraindicated (4) Major (227) Moderate (59)

Major

Etodolac Phenyl Salicylate Increased risk of bleeding Details Etodolac Piketoprofen Increased risk of bleeding Details Etodolac Piretanide Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Piroxicam Feldene Increased risk of bleeding Details Etodolac Polythiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Etodolac Prasugrel Effient An increased risk of bleeding Details Etodolac Prednisolone Flo-Pred® Increased risk of gastrointestinal ulcer or bleeding Details Etodolac Prednisone Deltasone Increased risk of gastrointestinal ulcer or bleeding Details Etodolac Proglumetacin Increased risk of bleeding Details Etodolac Propyphenazone Increased risk of bleeding Details Etodolac Proquazone Increased risk of bleeding Details Etodolac Protein C Ceprotin An increased risk of bleeding Details Etodolac Protriptyline An increased risk of bleeding Details Etodolac Quinethazone Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Reviparin An increased risk of bleeding Details Etodolac Rivaroxaban Xarelto An increased risk of bleeding Details Etodolac Rofecoxib Increased risk of bleeding Details Etodolac Salicylamide Increased risk of bleeding Details Etodolac Salicylic Acid Increased risk of bleeding Details Etodolac Salsalate Disalcid Increased risk of bleeding Details Etodolac Selexipag Uptravi An increased risk of bleeding Details Etodolac Sibutramine An increased risk of bleeding Details Etodolac Sodium Salicylate Increased risk of bleeding Details Etodolac Spironolactone Aldactone Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Etodolac Sulfasalazine Azulfidine Increased risk of bleeding Details Etodolac Sulfinpyrazone An increased risk of bleeding Details Etodolac Sulindac Clinoril® Increased risk of bleeding Details Etodolac Sulodexide An increased risk of bleeding Details Etodolac Tacrolimus Astagraf Acute renal failure Details Etodolac Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Etodolac Tenofovir Disoproxil Fumarate Increased risk of acute renal failure Details Etodolac Tenoxicam Increased risk of bleeding Details Etodolac Tianeptine An increased risk of bleeding Details Etodolac Tiaprofenic Acid Increased risk of bleeding Details Etodolac Ticagrelor Brilinta An increased risk of bleeding Details Etodolac Ticlopidine Ticlid® An increased risk of bleeding Details Etodolac Tinzaparin An increased risk of bleeding Details Etodolac Tirofiban An increased risk of bleeding Details Etodolac Tolfenamic Acid Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.