Etodolac

290 interactions 321 cited references
Also sold as: Lodine Lodine® Lodine® XL
About Etodolac

Etodolac is an NSAID used to relieve pain, swelling, and stiffness from osteoarthritis, rheumatoid arthritis, and other causes. Read the full Etodolac drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Opipramol Olsalazine
4 Contraindicated 227 Major 59 Moderate
All (290) Contraindicated (4) Major (227) Moderate (59)

Major

Etodolac Tolmetin Tolectin 600 Increased risk of bleeding Details Etodolac Torsemide Soaanz Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Trazodone Raldesy An increased risk of bleeding Details Etodolac Treprostinil Orenitram An increased risk of bleeding Details Etodolac Triamterene Dyrenium Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Etodolac Trichlormethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Trimipramine An increased risk of bleeding Details Etodolac Trolamine Salicylate Increased risk of bleeding Details Etodolac Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details Etodolac Valdecoxib Increased risk of bleeding Details Etodolac Venlafaxine An increased risk of bleeding Details Etodolac Vilazodone Viibryd An increased risk of bleeding Details Etodolac Vorapaxar Zontivity An increased risk of bleeding Details Etodolac Vortioxetine Trintellix An increased risk of bleeding Details Etodolac Warfarin Coumadin An increased risk of bleeding Details Etodolac Xipamide Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Etodolac Fondaparinux Injection Arixtra An increased risk of bleeding Details Etodolac Furosemide Injection Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Etodolac Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Etodolac Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Etodolac Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Etodolac Meloxicam Injection Alloxate Increased risk of bleeding Details Etodolac Melphalan Injection Alkeran An increased risk of bleeding Details Etodolac Mesalamine Rectal Canasa Increased risk of bleeding Details Etodolac Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Etodolac Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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