Everolimus and Danicopan: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Everolimus
Danicopan
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased P-gp substrate exposure
Interaction Deep Dive
Concomitant administration of danicopan with a P-gp substrate with narrow therapeutic index (NTI) may increase the plasma concentration of the P-gp substrate. In a drug interaction study, coadministration of a single oral dose of fexofenadine 180 mg with danicopan dosed to steady state (150 mg three times a day for 4 days) resulted in increased fexofenadine Cmax and AUC (0 to inf) by 1.4-fold and 1.6-fold, respectively. In an another study, coadministration of a single oral dose of tacrolimus (P-gp substrate) 2 mg with danicopan dosed to steady state (200 mg three times a day for 5 days) resulted in increased tacrolimus Cmax and AUC (0 to inf) by 1.1-fold and 1.5-fold, respectively. Dose adjustment might be necessary for P-gp substrates where minimal concentration changes may lead to serious adverse reactions1.
Why it happens (mechanism)
Inhibition of P-gp-mediated metabolism by danicopan
Literature reports
2 reports — tap to read
a) In a drug interaction study, coadministration of a single oral dose of fexofenadine (P-gp substrate) 180 mg with danicopan dosed to steady state (150 mg three times a day for 4 days) resulted in increased fexofenadine Cmax and AUC (0 to inf) by 1.4-fold and 1.6-fold, respectively 1.
b) In a drug interaction study, coadministration of a single oral dose of tacrolimus (P-gp substrate) 2 mg with danicopan dosed to steady state (200 mg three times a day for 5 days) resulted in increased tacrolimus Cmax and AUC (0 to inf) by 1.1-fold and 1.5-fold, respectively 1.
Common questions
Can I take Everolimus and Danicopan together?
Increased P-gp substrate exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Everolimus and Danicopan interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Everolimus or Danicopan need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VOYDEYA(TM) oral tablets, danicopan oral tablets. Alexion Pharmaceuticals, Inc. (Per manufacturer), Boston, MA, 2024. DailyMed
Keep reading about Everolimus
Keep reading about Danicopan
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