Febuxostat and Dextroamphetamine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Dextroamphetamine
Febuxostat
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrome
Interaction Deep Dive
The concomitant use of dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) and CYP2D6 inhibitors may increase the exposure of dextroamphetamine, the active metabolite of lisdexamfetamine compared to the use of the drug alone and also increase the risk of serotonin syndrome. If concomitant use of dextroamphetamine or lisdexamfetamine with CYP2D6 inhibitors is clinically warranted, initiate with lower doses and monitor patients for signs and symptoms of serotonin syndrome particularly during dextroamphetamine or lisdexamfetamine initiation and after a dosage increase. Serotonin syndrome symptoms may include mental status changes, autonomic instability, seizures, and/or gastrointestinal symptoms, neuromuscular symptoms. If serotonin syndrome occurs, discontinue dextroamphetamine or lisdexamfetamine and the CYP2D6 inhibitor. Consider an alternative drug that does not inhibit CYP2D61.
Why it happens (mechanism)
Inhibition of CYP2D6-mediated metabolism of dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine); additive serotonergic effects
Common questions
Can I take Febuxostat and Dextroamphetamine together?
Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrome Always confirm with your pharmacist or prescriber before making any change.
How serious is the Febuxostat and Dextroamphetamine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Febuxostat or Dextroamphetamine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: ARYNTA(TM) oral solution, lisdexamfetamine dimesylate oral solution. Azurity Pharmaceuticals, Inc. (per FDA), Woburn, MA, 2025. DailyMed
Keep reading about Dextroamphetamine
Keep reading about Febuxostat
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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